Patients in elective surgery, trauma & those undergoing open heart surgery in association w/ cardiopulmonary bypass. Discontinue immediately if hypersensitivity reaction occurs & appropriate treatment & supportive measures must be undertaken; 1st sign of clinically relevant renal injury, coagulopathy. Avoid use in patients w/ pre-existing renal dysfunction. Monitor renal function in hospitalised patients for at least 90 days; coagulation status in patients undergoing open heart surgery in association w/ cardiopulmonary bypass; liver function. Avoid fluid overload. Regularly assess fluid status & rate of infusion during treatment especially in patients w/ cardiac insufficiency. Administer sufficient fluid to avoid dehydration; saline based soln in metabolic alkalosis. Electrolyte abnormalities. Clinical evaluation & periodic lab determinations during prolonged therapy. Pregnancy & lactation.
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